Muscular Dystrophy News -- ScienceDaily

Muscular Dystrophy News -- ScienceDaily
  • Scientists identify new disease treatment path
    A previously unknown phenomenon -- that diseased muscle cells literally eat themselves to death -- has been discovered by researchers. The researchers say this previously unrecognised mechanism could have far reaching effects for the understanding and treatment of diseases including cancers and inflammatory diseases, as well as Duchenne muscular dystrophy.
  • Hope for muscular dystrophy patients: Harnessing gene helps repair muscle damage
    Researchers have successfully improved the ability of muscle to repair itself -- by artificially increasing levels of the BMI1 gene in the muscle-specific stem cells of mice with muscular dystrophy.
  • Video game technology helps measure upper extremity movement in patients with muscular dystrophy
    Researchers have developed a way to measure upper extremity movement in patients with muscular dystrophy using interactive video game technology. Their hope is to expand inclusion criteria for clinical trials to incorporate patients using wheelchairs.
  • Heart drugs offer new hope to slow cardiac damage in muscular dystrophy
    Early use of available heart failure drugs slows the progressive decline in heart function before symptoms are apparent in boys and young men with Duchenne muscular dystrophy (DMD), according to a new study.
  • Stem cells faulty in Duchenne muscular dystrophy, researchers find
    Like human patients, mice with a form of Duchenne muscular dystrophy undergo progressive muscle degeneration and accumulate connective tissue as they age. Now, researchers have found that the fault may lie at least partly in the stem cells that surround the muscle fibers.
  • Cardiac stem cell therapy may heal heart damage caused by Duchenne muscular dystrophy
    Injections of cardiac stem cells might help reverse heart damage caused by Duchenne muscular dystrophy, potentially resulting in a longer life expectancy for patients with the chronic muscle-wasting disease, researchers report.
  • Are my muscular dystrophy drugs working? Measuring muscle health with low-resolution ultrasound images
    People with muscular dystrophy could one day assess the effectiveness of their medication with the help of a smartphone-linked device, a new study in mice suggests. The study used a new method to process ultrasound imaging information that could lead to hand-held instruments that provide fast, convenient medical information.
  • Guideline offers direction in genetic testing for certain types of muscular dystrophy
    A new guideline recommends guidance on how doctors should evaluate the full picture—from symptoms, family history and ethnicity to a physical exam and certain lab test results—in order to determine what genetic tests may best diagnose a person’s subtype of limb-girdle or distal muscular dystrophy.
  • Out-of-step cells spur muscle fibrosis in Duchenne Muscular Dystrophy patients
    Like a marching band falling out of step, muscle cells fail to perform in unison in patients with Duchenne muscular dystrophy. Researchers reveal how this breakdown leads to the proliferation of stiff fibrotic tissue within muscles.
  • Researchers discover how circular RNA is created, find link to degenerative disease
    Our genetic information is stored in DNA, tiny strands of nucleic acid that contain instructions for the functioning of our bodies. To express this genetic data, our DNA is copied into RNA molecules, which then translate the instructions into proteins that perform tasks in our cells. In addition to known RNAs, circRNA molecules are abundant, yet little has been known about how they are produced, and next to nothing has been known about the role they play in disease. Now, researchers have discovered how circRNAs are produced.
  • New microscopy technique yields fresh data on muscular dystrophy
    A new microscopy technique yields resolution an order of magnitude better than previously possible. Through this new technique, the researchers showed that dystrophin was responsible for regulating tiny molecular fluctuations in calcium channels while muscles are in use. The discovery suggests that a lack of functional dystrophin alters the dynamics of ion channels -- helping to cause the defective mechanical responses and the calcium imbalance that impair normal muscle activity in patients with muscular dystrophy.
  • Delay in age of walking can herald muscular dystrophy in boys with cognitive delays
    The timing of a toddler's first steps is an important developmental milestone, but a slight delay in walking is typically not a cause of concern by itself. Now a duo of researchers has found that when walking and cognitive delays occur in concert, the combination could comprise the earliest of signals heralding a rare but devastating disorder known as Duchenne muscular dystrophy.
  • Muscular dystrophy: Repair the muscles, not the genetic defect
    A potential way to treat muscular dystrophy directly targets muscle repair instead of the underlying genetic defect that usually leads to the disease, researchers say. Muscular dystrophies are a group of muscle diseases characterized by skeletal muscle wasting and weakness. Mutations in certain proteins, most commonly the protein dystrophin, cause muscular dystrophy.
  • New genetic targets discovered in fight against muscle-wasting disease
    Findings of a new study offer the possibility of developing new ways of tackling an incurable condition known as muscle-wasting disease. To date, only six genes have been linked to the illness. Despite rigorous screening, at least 50% of patients have no detectable mutation in the 6 known genes. Now a breakthrough study has discovered two more genes linked to the disease.
  • Researchers discover key to making new muscles
    Cyclic bursts of a STAT3 inhibitor can replenish muscle stem cells and promote their differentiation into muscle fibers, scientists report. The findings are an important step toward developing and maintaining new muscle to treat muscle diseases.