Muscular Dystrophy News -- ScienceDaily

Muscular Dystrophy News -- ScienceDaily
  • iPS cells discover drug target for muscle disease
    Duchenne muscular dystrophy (DMD) is disease that leads to the degeneration of muscle due to dysfunctional expression of the protein dystrophin. A new iPS cell model found that the early stages of DMD development can be attributed to a specific family of ion channels that allows an abnormal influx of calcium to enter the cell. This same model can be used for drug discovery to correct the channel behavior, experts say.
  • Important regulation of cell invaginations discovered
    Lack of microinvaginations in the cell membrane, caveolae, can cause serious diseases such as lipodystrophy and muscular dystrophy. Researchers have now discovered a “main switch” that regulates the formation of these invaginations.
  • Muscle fibers grown in the lab offer new model for studying muscular dystrophy
    Investigators report that they have been able to drive cells to grow into muscle fibers, producing millimeter-long muscle fibers capable of contracting in a dish and multiplying in large numbers. This new method of producing muscle cells could offer a better model for studying muscle diseases, such as muscular dystrophy, and for testing out potential treatment options.
  • Inactivity reduces people's muscle strength
    It only takes two weeks of not using their legs for young people to lose a third of their muscular strength, leaving them on par with a person who is 40-50 years their senior, new research shows.
  • Cosmetic lip surgery may ease facial paralysis, small study suggests
    A cosmetic surgery that uses injections of hyaluronic acid to make lips appear fuller could also improve the lives of people with facial paralysis, according to results of a small study.
  • Gene discovery could lead to muscular dystrophy treatment
    Researchers have made a critical discovery about a gene involved in muscular dystrophy that could lead to future therapies for the currently untreatable disease. Facioscapulohumeral muscular dystrophy (FSHD) is a progressive wasting disease that affects the face, arms and shoulders. It is most commonly diagnosed in teenage or early adults, and though it is rarely fatal is it very debilitating.
  • 'Alzheimer's protein' plays role in maintaining eye health, muscle strength
    Amyloid precursor protein (APP), a key protein implicated in the development Alzheimer's disease, may play an important role in eye and muscle health. In a new report, scientists say they have discovered that when proteins that bind to the APP, called FE65 and FE65L1, are deleted, they cause cataracts and muscle weakness in mice.
  • Likely genetic source of muscle weakness found in six previously undiagnosed children
    Using state-of-the-art genetic technology, researchers have discovered the likely cause of a child's rare type of severe muscle weakness. The child was one of six cases in which investigators sequenced -- or decoded -- the genes of patients with Neuromuscular Disease and was then able to identify the genetic source, or likely genetic source, of each child's symptoms.
  • Potential treatment identified for myotonic muscular dystrophy
    A doctor who was one of the discoverers of the gene responsible for myotonic muscular dystrophy has now identified a therapeutic that could slow progression of muscle damage and muscle dysfunction associated with the disease.
  • Cardiac and respiratory function supported by abdominal muscles in muscular dystrophy
    The muscular dystrophies are known to target various muscle groups differentially. In addition to making limb muscles weak, muscular dystrophy (MD) can also lead to decreased function of specific muscles involved in respiration causing breathing difficulties as well as leading to cardiac problems. Using mouse models, researchers found that abdominal muscles may be severely involved in the muscular dystrophy process.
  • Bacterial defense mechanism targets duchenne muscular dystrophy
    A gene therapy technique that has the potential to treat more than half of the patients suffering from Duchenne Muscular Dystrophy by targeting a large region of the gene that contains many different mutations that cause the disease has been revealed by researchers.
  • New figures on two muscular dystrophy disorders
    Public health researchers report the freqency of two muscle-weakness disorders that strike mostly boys: Duchenne muscular dystrophy and Becker muscular dystrophy. The team found that about 1 in 5,000 boys in the United States, between 5 and 9 years old, have the inherited disorders. They also find that the diseases appear to affect Hispanic boys more often than white or African-American boys, for unknown reasons.
  • Towards a new weapon against muscular dystrophy
    The therapeutic potential of a new class of synthetic oligonucleotides in the treatment of Duchenne muscular dystrophy (DMD) using RNA "surgery" has been demonstrated by researchers. Tested in mice, this new generation of molecules proved to be clinically superior to those currently under evaluation in DMD patients, notably for restoring cardio-respiratory and central nervous system function.
  • Scientists develop active substance for fatal muscle wasting in male children
    Duchenne muscular dystrophy is a congenital disease which causes muscle degeneration and eventual death in teenagers. Recently, researchers have developed an active substance, which they together with an international team tested successfully.
  • Scientists identify new disease treatment path
    A previously unknown phenomenon -- that diseased muscle cells literally eat themselves to death -- has been discovered by researchers. The researchers say this previously unrecognised mechanism could have far reaching effects for the understanding and treatment of diseases including cancers and inflammatory diseases, as well as Duchenne muscular dystrophy.