Muscular Dystrophy News -- ScienceDaily

Muscular Dystrophy News -- ScienceDaily
  • Likely genetic source of muscle weakness found in six previously undiagnosed children
    Using state-of-the-art genetic technology, researchers have discovered the likely cause of a child's rare type of severe muscle weakness. The child was one of six cases in which investigators sequenced -- or decoded -- the genes of patients with Neuromuscular Disease and was then able to identify the genetic source, or likely genetic source, of each child's symptoms.
  • Potential treatment identified for myotonic muscular dystrophy
    A doctor who was one of the discoverers of the gene responsible for myotonic muscular dystrophy has now identified a therapeutic that could slow progression of muscle damage and muscle dysfunction associated with the disease.
  • Cardiac and respiratory function supported by abdominal muscles in muscular dystrophy
    The muscular dystrophies are known to target various muscle groups differentially. In addition to making limb muscles weak, muscular dystrophy (MD) can also lead to decreased function of specific muscles involved in respiration causing breathing difficulties as well as leading to cardiac problems. Using mouse models, researchers found that abdominal muscles may be severely involved in the muscular dystrophy process.
  • Bacterial defense mechanism targets duchenne muscular dystrophy
    A gene therapy technique that has the potential to treat more than half of the patients suffering from Duchenne Muscular Dystrophy by targeting a large region of the gene that contains many different mutations that cause the disease has been revealed by researchers.
  • New figures on two muscular dystrophy disorders
    Public health researchers report the freqency of two muscle-weakness disorders that strike mostly boys: Duchenne muscular dystrophy and Becker muscular dystrophy. The team found that about 1 in 5,000 boys in the United States, between 5 and 9 years old, have the inherited disorders. They also find that the diseases appear to affect Hispanic boys more often than white or African-American boys, for unknown reasons.
  • Towards a new weapon against muscular dystrophy
    The therapeutic potential of a new class of synthetic oligonucleotides in the treatment of Duchenne muscular dystrophy (DMD) using RNA "surgery" has been demonstrated by researchers. Tested in mice, this new generation of molecules proved to be clinically superior to those currently under evaluation in DMD patients, notably for restoring cardio-respiratory and central nervous system function.
  • Scientists develop active substance for fatal muscle wasting in male children
    Duchenne muscular dystrophy is a congenital disease which causes muscle degeneration and eventual death in teenagers. Recently, researchers have developed an active substance, which they together with an international team tested successfully.
  • Scientists identify new disease treatment path
    A previously unknown phenomenon -- that diseased muscle cells literally eat themselves to death -- has been discovered by researchers. The researchers say this previously unrecognised mechanism could have far reaching effects for the understanding and treatment of diseases including cancers and inflammatory diseases, as well as Duchenne muscular dystrophy.
  • Hope for muscular dystrophy patients: Harnessing gene helps repair muscle damage
    Researchers have successfully improved the ability of muscle to repair itself -- by artificially increasing levels of the BMI1 gene in the muscle-specific stem cells of mice with muscular dystrophy.
  • Video game technology helps measure upper extremity movement in patients with muscular dystrophy
    Researchers have developed a way to measure upper extremity movement in patients with muscular dystrophy using interactive video game technology. Their hope is to expand inclusion criteria for clinical trials to incorporate patients using wheelchairs.
  • Heart drugs offer new hope to slow cardiac damage in muscular dystrophy
    Early use of available heart failure drugs slows the progressive decline in heart function before symptoms are apparent in boys and young men with Duchenne muscular dystrophy (DMD), according to a new study.
  • Stem cells faulty in Duchenne muscular dystrophy, researchers find
    Like human patients, mice with a form of Duchenne muscular dystrophy undergo progressive muscle degeneration and accumulate connective tissue as they age. Now, researchers have found that the fault may lie at least partly in the stem cells that surround the muscle fibers.
  • Cardiac stem cell therapy may heal heart damage caused by Duchenne muscular dystrophy
    Injections of cardiac stem cells might help reverse heart damage caused by Duchenne muscular dystrophy, potentially resulting in a longer life expectancy for patients with the chronic muscle-wasting disease, researchers report.
  • Are my muscular dystrophy drugs working? Measuring muscle health with low-resolution ultrasound images
    People with muscular dystrophy could one day assess the effectiveness of their medication with the help of a smartphone-linked device, a new study in mice suggests. The study used a new method to process ultrasound imaging information that could lead to hand-held instruments that provide fast, convenient medical information.
  • Guideline offers direction in genetic testing for certain types of muscular dystrophy
    A new guideline recommends guidance on how doctors should evaluate the full picture—from symptoms, family history and ethnicity to a physical exam and certain lab test results—in order to determine what genetic tests may best diagnose a person’s subtype of limb-girdle or distal muscular dystrophy.